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Frozen-thawed transfer cycles: are they comparable with fresh?

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posted on 22.11.2019 by Edgar Mocanu, Evelyn Cottell, K Waite, Bernadette Hennelly, Claire Collins, Robert F. Harrison

Cryopreservation of zygotes and subsequent thaw and transfer is an established ART treatment. We assessed if success rates frozen-thawed (day 2) zygotes are comparable with the outcome in fresh cycles of treatment. We performed a prospective follow-up and analysis of all frozen (FZT) and fresh cycles of treatment during a 12 months period. One hundred and nineteen patients in the frozen-thawed and 652 in the fresh group had a transfer. The overall thaw-survival rate was 71.7%. Clinical pregnancy rates per thaw and transfer were respectively 15.1% and 21% in the frozen and 29.1% (per transfer) in the fresh group. Implantation rates in fresh and frozen cycles were 16% and 12.3% respectively. The pregnancy loss rate was higher in the FZT group (29% vs. 18.3%). Cryopreservation of good quality zygotes, after fresh transfer offers optimal success rates in subsequent frozen treatment. It also encourages consideration of elective single zygote transfers.

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The original article is available at imj.ie

Published Citation

Mocanu EV, Cottell E, Waite K, Hennelly B, Collins C, Harrison RF. Frozen-thawed transfer cycles: are they comparable with fresh? Irish Medical Journal. 2008;101(6):181-4.

Publication Date

01/06/2008

Publisher

Irish Medical Organisation

PubMed ID

18700513

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