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LC3B globular structures correlate with survival in esophageal adenocarcinoma.

journal contribution
posted on 23.11.2019 by Shereen El-Mashed, Tracey R. O'Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O'Sullivan, Anthony O'Grady, John Reynolds, Seamus O'Reilly, Gerald C. O'Sullivan, Sharon L. McKenna

BACKGROUND: Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.

METHODS: Esophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and 48 patients post neoadjuvant therapy were assembled into tissue microarrays prior to immunohistochemical analysis. Kaplan-Meier survival curves and log-rank tests were used to assess impact of LC3B expression on survival. Cox regression was used to examine association with clinical risk factors.

RESULTS: A distinct globular pattern of LC3B expression was found to be predictive of outcome in both patient groups, irrespective of treatment (p < 0.001). Multivariate analysis found that this was a strong independent predictor of poor prognosis (p < 0.001).

CONCLUSIONS: This distinctive staining pattern of LC3B represents a novel prognostic marker for resectable esophageal adenocarcinoma.

Funding

Egyptian Education Bureau, Higher Education Authority of Ireland, Breakthrough Cancer Research.

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The original article is available at www.biomedcentral.com

Published Citation

El-Mashed S, O'Donovan TR, Kay EW, Abdallah AR, Cathcart MC, O'Sullivan J, O'Grady A, Reynolds J, O'Reilly S, O'Sullivan GC, McKenna SL. LC3B globular structures correlate with survival in esophageal adenocarcinoma. BMC Cancer. 2015;15:582

Publication Date

12/08/2015

Publisher

BioMed Central

PubMed ID

26265176

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