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Meta-analysis of the molecular associations of mucinous colorectal cancer.

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posted on 22.11.2019 by Ian S. Reynolds, S J Furney, Elaine W. Kay, Deborah A. McNamara, Jochen HM Prehn, John P. Burke

BACKGROUND: Mucinous differentiation occurs in 5-15 per cent of colorectal adenocarcinomas. This subtype of colorectal cancer responds poorly to chemoradiotherapy and has a worse prognosis. The genetic aetiology underpinning this cancer subtype lacks consensus. The aim of this study was to use meta-analytical techniques to clarify the molecular associations of mucinous colorectal cancer.

METHODS: This study adhered to MOOSE guidelines. Databases were searched for studies comparing KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), p53 and p27 status between patients with mucinous and non-mucinous colorectal adenocarcinoma. A random-effects model was used for analysis.

RESULTS: Data from 46 studies describing 17 746 patients were included. Mucinous colorectal adenocarcinoma was associated positively with KRAS (odds ratio (OR) 1·46, 95 per cent c.i. 1·08 to 2·00, P = 0·014) and BRAF (OR 3·49, 2·50 to 4·87; P < 0·001) mutation, MSI (OR 3·98, 3·30 to 4·79; P < 0·001) and CIMP (OR 3·56, 2·85 to 4·43; P < 0·001), and negatively with altered p53 expression (OR 0·46, 0·31 to 0·67; P < 0·001).

CONCLUSION: The genetic origins of mucinous colorectal adenocarcinoma are predominantly associated with BRAF, MSI and CIMP pathways. This pattern of molecular alterations may in part explain the resistance to standard chemotherapy regimens seen in mucinous adenocarcinoma.

Funding

Funding for this study was provided by the Beaumont Hospital Colorectal Research Trust

History

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The original article is available at https://onlinelibrary.wiley.com

Published Citation

Reynolds IS, Furney SJ,Kay EW,McNamara DA, Prehn JA, Burke JP. A systematic review and meta-analysis of the molecular associations of mucinous colorectal cancer. British Journal of Surgery. 2019;106(6):682-691

Publication Date

01/05/2019

Publisher

John Wiley & Sons

PubMed ID

30945755

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