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Non-genomic actions of aldosterone: From receptors and signals to membrane targets.

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posted on 22.11.2019 by Ruth Dooley, Brian J. Harvey, Warren Thomas

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.

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This article is also available at http://www.sciencedirect.com/science/article/pii/S0303720711003996

Published Citation

Dooley R, Harvey BJ, Thomas W. Non-genomic actions of aldosterone: From receptors and signals to membrane targets. Molecular and Cellular endocrinology. 2011 [Epub ahead of print]

Publication Date

01/07/2011

Publisher

North Holland Publishing

PubMed ID

21801805

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