File(s) under embargo

223

days

5

hours

until file(s) become available

Polygenic risk score of non-melanoma skin cancer predicts post-transplant skin cancer across multiple organ types

journal contribution
posted on 19.05.2020 by Caragh Stapleton, Bao-Li Chang, Brendan Keating, Peter J. Conlon, Gianpiero Cavalleri

Polygenic risk scores (PRS) calculated from genome‐wide association studies (GWAS) of non-melanoma skin cancer (NMSC) in a general, non-transplant setting, have recently been shown to predict risk of, and time to post-renal transplant skin cancer. In this study, we set out to test these findings in a cohort of heart, lung and liver transplant patients to see if these scores could be applied across different organ transplant types.

Using the PRS from Stapleton et al. (2018), PRS were calculated for each sample across a European ancestry heart, lung and liver transplant cohorts (n = 523) and tested as predictors time to NMSC post-transplant. The top PRS, squamous cell carcinoma (SCC) pT1x10-5,

(n SNPs= 1953), SCC pT1x10-6 and SCC pT1x10-6 (n SNPs = 1061) was significantly predictive in the time to NMSC, SCC and basal cell carcinoma (BCC) analysis across organ (p = 0.006, 0.02 and 0.02 respectively). We observed here a similar direction of effect and effect size [NMSC HR = 1.31(1.08-1.59)] to that in the original, discovery study, with increased polygenic burden leading to a faster time to developing NMSC.

In summary, we found that PRS of NMSC calculated from GWAS of NMSC in non-transplant populations independently replicated in this cohort of heart, lung and liver transplant.

Funding

C.P.S is supported by the Irish Research Council and Punchestown Kidney Research Fund (grant number EPSPG2015).

History

Comments

This is the peer reviewed version of the following article: Stapleton CP, Chang BL, Keating B, Conlon PJ, Cavalleri GP. Polygenic risk score of non-melanoma skin cancer predicts post-transplant skin cancer across multiple organ types. Clinical Transplantation. 2020;May 13 [epub ahead of print], which has been published in final form at https://doi.org/10.1111/ctr.13904. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Published Citation

Stapleton CP, Chang BL, Keating B, Conlon PJ, Cavalleri GP. Polygenic risk score of non-melanoma skin cancer predicts post-transplant skin cancer across multiple organ types. Clinical Transplantation. 2020;May 13 [epub ahead of print]

Publication Date

13/05/2020

PubMed ID

32400091

Exports

Logo branding

Categories

Exports