SARS-CoV-2 detection viral load and infectivity.pdf (988.93 kB)

SARS-CoV-2 detection, viral load and infectivity over the course of an infection.

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journal contribution
posted on 30.10.2020, 16:55 by Kieran A Walsh, Karen Jordan, Barbara Clyne, Daniela Rohde, Linda Drummond, Paula Byrne, Susan Ahern, Paul G Carty, Kirsty K O'Brien, Eamon O'Murchu, Michelle O'Neill, Susan Smith, Mairin Ryan, Patricia Harrington

Objectives: To summarise the evidence on the detection pattern and viral load of SARS-CoV-2 over the course of an infection (including any asymptomatic or pre-symptomatic phase), and the duration of infectivity.

Methods: A systematic literature search was undertaken in PubMed, Europe PubMed Central and EMBASE from 30 December 2019 to 12 May 2020.

Results: We identified 113 studies conducted in 17 countries. The evidence from upper respiratory tract samples suggests that the viral load of SARS-CoV-2 peaks around symptom onset or a few days thereafter, and becomes undetectable about two weeks after symptom onset; however, viral loads from sputum samples may be higher, peak later and persist for longer. There is evidence of prolonged virus detection in stool samples, with unclear clinical significance. No study was found that definitively measured the duration of infectivity; however, patients may not be infectious for the entire duration of virus detection, as the presence of viral ribonucleic acid may not represent transmissible live virus.

Conclusion: There is a relatively consistent trajectory of SARS-CoV-2 viral load over the course of COVID-19 from respiratory tract samples, however the duration of infectivity remains uncertain.

Funding

Health Research Board (HRB-CICER-2016-1871)

History

Comments

The original article is available at https://www.journals.elsevier.com

Published Citation

Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, Aherne S, Carty PG, O’Brien KK, O’Murchu E, O’Neill M, Smith SM, Ryan M, Harrington P. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. Journal of Infection. 2020;81(3):357-371.

Publication Date

29 June 2020

PubMed ID

32615199

Department/Unit

  • General Practice
  • HRB Centre for Primary Care Research

Research Area

  • Population Health and Health Services

Publisher

Elsevier

Version

  • Accepted Version (Postprint)

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