Selenium Status is Associated with Colorectal Cancer risk in the.pdf (602.93 kB)

Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort

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posted on 22.11.2019, 17:00 by David J. Hughes, Veronika Fedirko, Mazda Jenab, Lutz Schomburg, Catherine Meplan, Heinz Freisling, H B. Bueno-de-Mesquita, Sandra Hybsier, Niels-Peter Becker, Magdalena Czuban, Anne Tjonneland, Malene Outzen, Marie-Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman Kuhn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Petra H. Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria-Dolores Chirlaque, Maria-Jose Sanchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E. Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ramon Quiros, Magdalena Stepien, So Y. Kong, Talita Duarte-Salles, Elio Riboli, John E. Hesketh

Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 µg/L and 4.3 mg/L in cases and 85.6 µg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR = 0.92, 95%CI: 0.82-1.03 per 25 µg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (Ptrend = 0.032; per 25 µg/L Se increase, IRR = 0.83, 95%CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (Ptrend = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95%CI: 0.82-0.98) with the association more apparent in women (Ptrend = 0.004; IRR = 0.82, 95%CI: 0.72-0.94 per 0.806 mg/L increase) than men (Ptrend = 0.485; IRR = 0.98, 95%CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.

History

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This is the pre-peer reviewed version of the following article: Hughes DJ, Fedirki V, Jenab M, Schomburg L, Meplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjonneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kuhn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters P, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sanchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quiros JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE. Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort. International Journal of Cancer. Article first published online: 21 JUL 2014, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ijc.29071/pdf DOI: 10.1002/ijc.29071

Published Citation

Hughes DJ, Fedirki V, Jenab M, Schomburg L, Meplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjonneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kuhn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters P, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sanchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quiros JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE. Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort. International Journal of Cancer. Article first published online: 21 JUL 2014. DOI: 10.1002/ijc.29071

Publication Date

01/07/2014

PubMed ID

25042282

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