Significant gynecological bleeding in women with low von Willebra.pdf (861.38 kB)
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Significant gynecological bleeding in women with low von Willebrand factor levels.

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posted on 22.11.2019 by Michelle Lavin, Sonia Aguila, Niall Dalton, Margaret Nolan, Mary Byrne, Kevin Ryan, Barry White, Niamh M. O'Connell, Jamie O'Sullivan, Jorge Di Paola, Paula D. James, James S. O'Donnell

Gynecological bleeding is frequently reported in women with von Willebrand disease (VWD). Low von Willebrand factor (VWF) may be associated with significant bleeding phenotype despite only mild plasma VWF reductions. The contribution of gynecological bleeding to this phenotype has yet to be described. The optimal clinical bleeding assessment tool (BAT) to evaluate bleeding remains unclear. Using a standardized approach to phenotypic assessment, we evaluated gynecological bleeding and directly compared the Condensed Molecular and Clinical Markers for the Diagnosis and Management of type 1 VWD (Condensed MCMDM-1 VWD) and International Society on Thrombosis and Haemostasis (ISTH) BAT scores in 120 women enrolled in the Low von Willebrand in Ireland Cohort study. Heavy menstrual bleeding (HMB) was reported in 89% of female participants; 45.8% developed iron deficiency. Using identical data, Condensed MCMDM-1 VWD menorrhagia domain scores were significantly lower than ISTH BAT scores (2 vs 3;

Funding

Irish Health Research Board Health Research Award (HRA-POR-2014-529) (J.S.O.) and a Science Foundation Ireland Principal Investigator Award (11/PI/1066) (J.S.O.).

History

Comments

This research was originally published in Blood Advances. Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O’Connell NM, O’Sullivan JM, Di Paola J, James PD, O’Donnell JS. Blood Adv. 2018;2(14):1784-1791. © the American Society of Hematology.

Published Citation

Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O’Connell NM, O’Sullivan JM, Di Paola J, James PD, O’Donnell JS. Blood Advances. 2018;2(14):1784-1791

Publication Date

24/07/2018

Publisher

American Society of Hematology

PubMed ID

30042144

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