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Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome

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posted on 23.11.2019 by Dan Wu, Shane Cheung, Corry James O'Sullivan, Yinghua Gao, Zhi-Long Chen, Donal F. O'Shea

The contribution of imaging with near infrared (NIR) fluorophores to the elucidation of complex biological processes continues to rapidly expand. New tools for mild selective bioconjugation are strongly desirable for the construction of NIR labelled biomolecules. This work presents the synthesis and evaluation of a strained alkyne substituted NIR BF2-azadipyrromethene (NIR-AZA) which can conjugate in water with azido-homoalanine and cRGD peptide within 30 min at rt. Imaging analysis of the NIR-AZA–cRGD conjugate in vitro and in vivo showed efficient cellular uptake and good in vivo tumor targeting properties, illustrating the potential for translation to clinical imaging.

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The original paper is available at https://pubs.rsc.org

Published Citation

Wu D, Cheung S, O'Sullivan CJ, Gao Y, Chen Zl, O'Shea DF. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances. 2016;6:87373-87379

Publication Date

07/09/2016

Publisher

Royal Society of Chemistry

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