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Targeting IRFs by ubiquitination: regulating antiviral responses.

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posted on 22.11.2019 by Rowan Higgs, Caroline A. Jefferies
The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.

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This article is also available at http://www.biochemsoctrans.org/bst/036/0453/bst0360453.htm

Published Citation

Higgs R, Jefferies CA. Targeting IRFs by ubiquitination: regulating antiviral responses. Biochemical Society Transactions 2008;36(3):453-8.

Publication Date

01/06/2008

Publisher

Portland Press On The Behalf Of The Biochemical Society

PubMed ID

18481980

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