Targeting IRFs by ubiquitination: regulating antiviral responses.
journal contributionposted on 22.11.2019 by Rowan Higgs, Caroline A. Jefferies
Any type of content formally published in an academic journal, usually following a peer-review process.
The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.