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The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon.

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posted on 22.11.2019 by Joseph B J Ward, Magdalena S. Mroz, Stephen J. Keely

Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and colonic motility. Here, we show that TGR5 is also expressed on colonic epithelial cells and that its activation decreases basal secretory tone and inhibits cholinergic-induced secretory responses. Our data demonstrate a new role for TGR5 in regulating colonic fluid and electrolyte transport and suggest that the receptor represents a good therapeutic target for intestinal transport disorders.

Funding

Principal Investigator Award from Science Foundation Ireland to SJK and by NBIP Ireland funded under the Higher Education Authority PRTLI Cycle 4.

History

Comments

This is the peer reviewed version of the following article: Ward JB, Mroz MS, Keely SJ. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterology & Motility. 2013; 25(8):708-11 which has been published in final form at 10.1111/nmo.12148. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Published Citation

Ward JB, Mroz MS, Keely SJ. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterology & Motility. 2013; 25(8):708-11

Publication Date

01/08/2013

Publisher

Wiley

PubMed ID

23634890

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