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The genetic landscape of Scotland and the Isles.

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posted on 22.11.2019 by Edmund Gilbert, Seamus O'Reilly, Michael Merrigan, Darren McGettigan, Veronique Vitart, Peter K. Joshi, David W. Clark, Harry Campbell, Caroline Hayward, Susan M. Ring, Jean Golding, Stephanie Goodfellow, Pau Navarro, Shona M. Kerr, Carmen Amador, Archie Campbell, Chris S. Haley, David J. Porteous, Gianpiero L. Cavalleri, James F. Wilson

Britain and Ireland are known to show population genetic structure; however, large swathes of Scotland, in particular, have yet to be described. Delineating the structure and ancestry of these populations will allow variant discovery efforts to focus efficiently on areas not represented in existing cohorts. Thus, we assembled genotype data for 2,554 individuals from across the entire archipelago with geographically restricted ancestry, and performed population structure analyses and comparisons to ancient DNA. Extensive geographic structuring is revealed, from broad scales such as a NE to SW divide in mainland Scotland, through to the finest scale observed to date: across 3 km in the Northern Isles. Many genetic boundaries are consistent with Dark Age kingdoms of Gaels, Picts, Britons, and Norse. Populations in the Hebrides, the Highlands, Argyll, Donegal, and the Isle of Man show characteristics of isolation. We document a pole of Norwegian ancestry in the north of the archipelago (reaching 23 to 28% in Shetland) which complements previously described poles of Germanic ancestry in the east, and "Celtic" to the west. This modern genetic structure suggests a northwestern British or Irish source population for the ancient Gaels that contributed to the founding of Iceland. As rarer variants, often with larger effect sizes, become the focus of complex trait genetics, more diverse rural cohorts may be required to optimize discoveries in British and Irish populations and their considerable global diaspora.

Funding

The Wellcome Trust. Scottish Funding Council. Royal Society, Arthritis Research UK and the European Union Framework Programme 6. Science Foundation Ireland. European Regional Development Fund. FutureNeuro industry.

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The original article is available at https://www.pnas.org

Published Citation

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Vitart V, Joshi PK, Clark DW, Campbell H, Hayward C, Ring SM, Golding J, Goodfellow S, Navarro P, Kerr SM, Amador C, Campbell A, Haley CS, Porteous DJ, Cavalleri GL, Wilson JF. The genetic landscape of Scotland and the Isles. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(38):19064-19070

Publication Date

17/09/2019

Publisher

National Academy of Sciences

PubMed ID

31481615

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