Fridman et al.pdf (7.04 MB)

Therapeutic Targeting of the Colorectal Tumor Stroma

Download (7.04 MB)
journal contribution
posted on 31.03.2020, 08:49 by Wolf Herman Fridman, Ian Miller, Catherine Sautès-Fridman, Annette Byrne
Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that are associated with patient outcomes and discuss potential therapeutic agents that target these features.

Funding

Horizon 2020 Research and Innovation Programme (Grant Agreement No. 754923 “ COLOSSUS”)

Science Foundation Ireland grant 13/CDA/2183 ”COLOFORETELL’

Health Research Board grant ILP-POR-2019-066

WHF, CSF receive funding from INSERM, Université de Paris, Sorbonne University, CARPEM T8, the Labex Immuno-Oncology Excellence Program, Institut du Cancer (INCa), HTE Plan Cancer (C1608DS), and the Cartes d’Identité des Tumeurs (CIT) Program from the Ligue Nationale Contre le Cancer

History

Comments

This article is also available at https://www.gastrojournal.org

Published Citation

Fridman WH, Miller I, Sautes-Fridman C, Byrne AT. Therapeutic Targeting of the Colorectal Tumor Stroma. Gastroenterology. 2020;158(2):303-321

Publication Date

14/10/2019

Publisher

Elsevier

PubMed ID

31622621

Exports

Logo branding

Exports