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3D-extrusion printing of stable constructs composed of photoresponsive polypeptide hydrogels

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journal contribution
posted on 16.04.2021, 15:30 by Robert Murphy, Scott Kimmins, Alan Hibbitts, Andreas Heise
The development of printable hydrogels with functional responsive crosslinking is vital to new age 3D printing materials in biomedical science. Disclosed here is a 3D printable UV responsive crosslinking system based on polypeptides incorporating glutamic acid, isoleucine and nitrobenzyl (NB) protected cysteine groups in a random and block copolymer. The hydrogel ink, encompassing the copolypeptide hydrogel carrier and 4-arm PEG-propiolate, can be readily extruded to produce mechanically stable constructs consisting of a number of geometries due to their remarkable shear-thinning ability. Exploiting the use of a catalyst free thiol-yne click chemistry between the cysteine residues and the propiolate groups upon UV curing, crosslinked hydrogel constructs with greater than 10 layers are fully stabilised and show improved stiffness which allow for them to be easily manipulated. This work can potentially offer a new crosslinking tool to explore in the field of 3D printing, providing highly stable hydrogel structures.

Funding

Science Foundation Ireland (SFI) Principle Investigator Award 13/IA/1840(T)

History

Comments

The original article is available at https://pubs.rsc.org

Published Citation

Murphy RD, Kimmins S, Hibbitts AJ, Heise A. 3D-extrusion printing of stable constructs composed of photoresponsive polypeptide hydrogels. Polymer Chemistry. 2019;10(34):4675-4682

Publication Date

30 July 2019

Department/Unit

  • Amber (Advanced Material & Bioengineering Research) Centre
  • Anatomy and Regenerative Medicine
  • Chemistry
  • Cu00daRAM Centre for Research in Medical Devices
  • RCSI Tissue Engineering Group (TERG)

Research Area

  • Respiratory Medicine
  • Chemistry and Pharmaceutical Sciences
  • Biomaterials and Regenerative Medicine
  • Immunity, Infection and Inflammation

Publisher

Royal Society of Chemistry (RSC)

Version

  • Accepted Version (Postprint)

Exports