Royal College of Surgeons in Ireland
DRUDIS-D-20-00231. Accepted.docx (192.67 kB)
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A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?

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journal contribution
posted on 2021-03-03, 11:47 authored by Danielle NaderDanielle Nader, Gerard CurleyGerard Curley, Steven KerriganSteven Kerrigan
Sepsis is a life-threatening condition caused by the response of the body to an infection, and has recently been regarded as a global health priority because of the lack of effective treatments available. Vascular endothelial cells have a crucial role in sepsis and are believed to be a major target of pathogens during the early stages of infection. Accumulating evidence suggests that common sepsis pathogens, including bacteria, fungi, and viruses, all contain a critical integrin recognition motif, Arg-Gly-Asp (RGD), in their major cell wall-exposed proteins that might act as ligands to crosslink to vascular endothelial cells, triggering systemic dysregulation resulting in sepsis. In this review, we discuss the potential of anti-integrin therapy in the treatment of sepsis and septic shock.


Science Foundation Ireland (SFI) under Grant Number 13/CDA/2119

Enterprise Ireland (EI) under Grant Number CF-2017-0684-P



The original article is available at

Published Citation

Nader D, Curley GF, Kerrigan SW. A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets? Drug Discovery Today. 2020(12):2317-2325.

Publication Date

6 October 2020

PubMed ID



  • Anaesthetics and Critical Care
  • Beaumont Hospital
  • School of Pharmacy and Biomolecular Sciences
  • Irish Centre for Vascular Biology

Research Area

  • Vascular Biology
  • Biomaterials and Regenerative Medicine
  • Immunity, Infection and Inflammation


Elsevier BV


  • Accepted Version (Postprint)