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Absence of malaria-associated coagulopathy in asymptomatic plasmodium falciparum infection.....pdf (580.02 kB)

Absence of malaria-associated coagulopathy in asymptomatic plasmodium falciparum infection: results from a cross-sectional study in the Ashanti Region, Ghana

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posted on 2023-05-10, 13:34 authored by Christina Charlotte Rolling, Richard O Phillips, Kabiru Mohammed Abass, Joseph Ken Adu Poku, Samuel Osei-Mireku, Bright Osei-Wusu, William Thompson, Christof D Vinnemeier, Lena Huebl, Florian Langer, Paul Francke, Piotr Kuta, Sandra Konrath, Thomas Renné, Egbert Tannich, Thierry Rolling, Melina Heinemann

Background: Coagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degree of coagulation abnormality correlates with parasitemia and disease severity. Chronic asymptomatic malaria has been associated with increased morbidity. However, the role of coagulation activation in asymptomatic, semi-immune individuals remains unclear. This study investigates the potential effect of asymptomatic P falciparum infection on coagulation activation in semi-immune Ghanaian adults.

Methods: Blood from asymptomatic Ghanaian adults with P falciparum blood stage infection detectable by polymerase chain reaction (PCR) or by both PCR and rapid diagnostic test and from noninfected individuals, was investigated. Markers of coagulation activation including global coagulation tests, D-dimer, antithrombin III, fibrinogen, and von Willebrand factor antigen were tested. Furthermore, blood count, inflammation markers, and liver and kidney function tests were assessed.

Results: Acquired coagulopathy was not found in asymptomatic P falciparum infection. Asymptomatic malaria was associated with significantly lower platelet counts. Systemic inflammation markers and liver and kidney function tests were not altered compared to noninfected controls.

Conclusions: There is no laboratory evidence for acquired coagulopathy in adults with asymptomatic P falciparum malaria in highly endemic regions. Lack of laboratory evidence for systemic inflammation and liver and kidney dysfunction indicates that asymptomatic malaria may not be associated with significant morbidity.

Funding

Bayer AG

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, 438122637)

DFG grant P6/KFO 306

History

Comments

The original article is available at https://academic.oup.com/

Published Citation

Rolling CC. Absence of malaria-associated coagulopathy in asymptomatic plasmodium falciparum infection: results from a cross-sectional study in the Ashanti Region, Ghana. Open Forum Infect Dis. 2023;10(3):ofad074.

Publication Date

18 February 2023

PubMed ID

36968961

Department/Unit

  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences

Publisher

Published by Oxford University Press

Version

  • Published Version (Version of Record)