Royal College of Surgeons in Ireland
Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future Therapeutics.pdf (2.8 MB)

Advancing our understanding of corneal herpes simplex virus-1 immune evasion mechanisms and future therapeutics

Download (2.8 MB)
journal contribution
posted on 2022-06-07, 16:32 authored by Emily Greenan, Sophie Gallagher, Rana Khalil, Conor MurphyConor Murphy, Joan Ni Gabhann-DromgooleJoan Ni Gabhann-Dromgoole
Herpes stromal keratitis (HSK) is a disease that commonly affects the cornea and external eye and is caused by Herpes Simplex Virus type 1 (HSV-1). This virus infects approximately 66% of people worldwide; however, only a small portion of these people will develop symptoms in their lifetime. There is no cure or vaccine available for HSV-1; however, there are treatments available that aim to control the inflammation caused by the virus and prevent its recurrence. While these treatments are beneficial to those suffering with HSK, there is a need for more effective treatments to minimise the need for topical steroids, which can have harmful effects, and to prevent bouts of disease reactivation, which can lead to progressive corneal scarring and visual impairment. This review details the current understanding of HSV-1 infection and discusses potential novel treatment options including microRNAs, TLRs, mAbs, and aptamers.


Royal Victoria Eye and Ear Hospital Research Foundation Grant 1805



The original article is available at

Published Citation

Greenan E, Gallagher S, Khalil R, Murphy CC, Ní Gabhann-Dromgoole J. Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future Therapeutics. Viruses. 2021;13(9):1856

Publication Date

17 September 2021

PubMed ID



  • Ophthalmology
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Chemistry and Pharmaceutical Sciences
  • Health Professions Education
  • Surgical Science and Practice
  • Biomaterials and Regenerative Medicine
  • Immunity, Infection and Inflammation




  • Published Version (Version of Record)