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Aging alters rhythms in immunity

journal contribution
posted on 23.06.2022, 08:12 by Annie CurtisAnnie Curtis, Richard Carroll

A new study shows that the transcription factor KLF4 has a role in the maintenance of circadian immune responses. Loss of KLF4 activity contributes to the age-associated immune dysfunction. 

History

References

Comments

The original article is available at https://www.nature.com/

Published Citation

Curtis AM, Carroll RG. Aging alters rhythms in immunity. Nat Immunol. 2022;23(2):153-154

Publication Date

25 January 2022

External DOI

PubMed ID

35079158

Department/Unit

  • School of Pharmacy and Biomolecular Sciences
  • Tissue Engineering Research Group (TERG)

Research Area

  • Immunity, Infection and Inflammation
  • Biomaterials and Regenerative Medicine
  • Vascular Biology

Publisher

Nature America Inc.

Version

  • Accepted Version (Postprint)

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Categories

Keywords

Circadian RhythmImmunologyimmune functionlive longerlifespanImmune Dysregulationagingchronic diseaseImmunosenescenceKrüppel-like factor 4 (KLF4)circadian immune regulation

Licence

CC BY-NC-SA 4.0

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