An in vitro visual study of fugitive aerosols released during aerosol therapy to an invasively ventilated simulated patient.pdf (1.56 MB)
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An in vitro visual study of fugitive aerosols released during aerosol therapy to an invasively ventilated simulated patient

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journal contribution
posted on 15.03.2022, 14:51 by Marc Mac Giolla Eain, Mary Joyce, Ronan MacLoughlinRonan MacLoughlin
COVID-19 can cause serious respiratory complications resulting in the need for invasive ventilatory support and concurrent aerosol therapy. Aerosol therapy is considered a high risk procedure for the transmission of patient derived infectious aerosol droplets. Critical-care workers are considered to be at a high risk of inhaling such infectious droplets. The objective of this work was to use noninvasive optical methods to visualize the potential release of aerosol droplets during aerosol therapy in a model of an invasively ventilated adult patient. The noninvasive Schlieren imaging technique was used to visualize the movement of air and aerosol. Three different aerosol delivery devices: (i) a pressurized metered dose inhaler (pMDI), (ii) a compressed air driven jet nebulizer (JN), and (iii) a vibrating mesh nebulizer (VMN), were used to deliver an aerosolized therapeutic at two different positions: (i) on the inspiratory limb at the wye and (ii) on the patient side of the wye, between the wye and endotracheal tube, to a simulated intubated adult patient. Irrespective of position, there was a significant release of air and aerosol from the ventilator circuit during aerosol delivery with the pMDI and the compressed air driven JN. There was no such release when aerosol therapy was delivered with a closed-circuit VMN. Selection of aerosol delivery device is a major determining factor in the release of infectious patient derived bioaerosol from an invasively mechanically ventilated patient receiving aerosol therapy.

Funding

Aerogen Limited

History

Comments

The original article is available at https://www.tandfonline.com/

Published Citation

Mac Giolla Eain M, Joyce M, MacLoughlin R. An in vitro visual study of fugitive aerosols released during aerosol therapy to an invasively ventilated simulated patient. Drug Deliv. 2021;28(1):1496-1500.

Publication Date

14 Jul 2021

PubMed ID

34259091

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Publisher

Informa UK Limited

Version

  • Published Version (Version of Record)