Sabherwal et al_ApoE elevation is associated with the Persistence of Psychotic Experiences.pdf (690.31 kB)
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ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort.

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posted on 15.03.2021, 17:47 by Sophie Sabherwal, Melanie FockingMelanie Focking, Jane A English, Stephen Fitzsimons, Magdalena Hryniewiecka, Kieran Wynne, Caitriona Scaife, Colm HealyColm Healy, Mary CannonMary Cannon, Orina Belton, Stanley Zammit, Gerard Cagney, David CotterDavid Cotter
Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences.

Funding

Irish Health Research Board through a Clinician Scientist Award

Wellcome (Grant ref.: 102215/2/13/2)

University of Bristol

NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol

UK Medical Research Council

History

Comments

The original article is available at https://www.sciencedirect.com

Published Citation

Sabherwal S, Föcking M, English JA, Fitzsimons S, Hryniewiecka M, Wynne K, Scaife C, Healy C, Cannon M, Belton O, Zammit S, Cagney G, Cotter DR. ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort. Schizophrenia Research. 2019;209:141-147.

Publication Date

10 May 2019

PubMed ID

31080155

Department/Unit

  • Beaumont Hospital
  • Psychiatry

Research Area

  • Neurological and Psychiatric Disorders
  • Population Health and Health Services

Publisher

Elsevier

Version

  • Accepted Version (Postprint)