ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort.
journal contributionposted on 15.03.2021, 17:47 by Sophie Sabherwal, Melanie FockingMelanie Focking, Jane A English, Stephen Fitzsimons, Magdalena Hryniewiecka, Kieran Wynne, Caitriona Scaife, Colm HealyColm Healy, Mary CannonMary Cannon, Orina Belton, Stanley Zammit, Gerard Cagney, David CotterDavid Cotter
Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences.
Irish Health Research Board through a Clinician Scientist Award
Wellcome (Grant ref.: 102215/2/13/2)
University of Bristol
NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol
UK Medical Research Council
CommentsThe original article is available at https://www.sciencedirect.com
Published CitationSabherwal S, Föcking M, English JA, Fitzsimons S, Hryniewiecka M, Wynne K, Scaife C, Healy C, Cannon M, Belton O, Zammit S, Cagney G, Cotter DR. ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort. Schizophrenia Research. 2019;209:141-147.
Publication Date10 May 2019
- Beaumont Hospital
- Neurological and Psychiatric Disorders
- Population Health and Health Services
- Accepted Version (Postprint)