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Apolipoprotein A-I enhances activated protein C cytoprotective activity

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journal contribution
posted on 30.04.2021, 14:01 by Eimear M Gleeson, Aisling RehillAisling Rehill, Orla Willis FoxOrla Willis Fox, Fionnuala Ni Ainle, Cormac McDonnell, Hannah RusheHannah Rushe, Sean McCluskey, James O'DonnellJames O'Donnell, Roger PrestonRoger Preston

High-density lipoprotein and apolipoprotein A-I enhance activated protein C cytoprotective activity.

High-density lipoprotein and apolipoprotein A-I significantly increase the rate at which activated protein C degrades cytotoxic extracellular histones.

Funding

Science Foundation Ireland Career Development Award (15/CDA/3499)

Technology and Innovation Development Award (18/TIDA/6001)

National Children’s Research Centre Project Award (C/18/3)

History

Comments

This research was originally published in Blood Advances. Gleeson EM, Rehill AM, Willis Fox O, Ni Ainle F, McDonnell CJ, Rushe HJ, McCluskey S, O'Donnell JS, Preston RJS. Apolipoprotein A-I enhances activated protein C cytoprotective activity. Blood Advances. 2020;4(11):2404-2408. © the American Society of Hematology.

Published Citation

Gleeson EM, Rehill AM, Willis Fox O, Ni Ainle F, McDonnell CJ, Rushe HJ, McCluskey S, O'Donnell JS, Preston RJS. Apolipoprotein A-I enhances activated protein C cytoprotective activity. Blood Advances. 2020;4(11):2404-2408.

Publication Date

2 June 2020

PubMed ID

32484855

Department/Unit

  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Health Professions Education
  • Vascular Biology

Publisher

American Society of Hematology

Version

  • Published Version (Version of Record)