Royal College of Surgeons in Ireland
2 files

Apoptotic cell death in disease - current understanding of the NCCD 2023

journal contribution
posted on 2023-06-29, 11:33 authored by Ilio Vitale, Jochen PrehnJochen Prehn, Lorenzo Galluzzi

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease. 


Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 #20417 and IG 2022 #27685)

Italian Institute for Genomic Medicine (Candiolo, Turin, Italy)

Compagnia di San Paolo (Torino, Italy)

Ministro dell’Università (Italy) progetto Heal Italia PE6

US DoD BCRP (#BC180476P1; #BC210945)

Transformative Breast Cancer Consortium Grant from the US DoD BCRP (#W81XWH2120034)

U54 grant from NIH/NCI (#CA274291)

2019 Laura Ziskin Prize in Translational Research (#ZP-6177)

Stand Up to Cancer (SU2C)

Mantle Cell Lymphoma Research Initiative (MCL-RI

Leukemia and Lymphoma Society (LLS)

Rapid Response Grant from the Functional Genomics Initiative (New York, US)

Dept. of Radiation Oncology at Weill Cornell Medicine (New York, US)

Lytix Biopharma (Oslo, Norway)

Promontory (New York, US)

Onxeo (Paris, France)

Luke Heller TECPR2 Foundation (Boston, US)

Sotio a.s. (Prague, Czech Republic)

Ricerchiamo (Brescia, Italy)

Noxopharm (Chatswood, Australia)

Ligue contre le Cancer (équipe labellisée)

Agence National de la Recherche (ANR) – Projets blancs


Association pour la recherche sur le cancer (ARC)

Cancéropôle Ile-de-France


Equipex Onco-Pheno-Screen

European Joint Programme on Rare Diseases (EJPRD)

European Research Council (ICD-Cancer)

European Union Horizon 2020 Projects Oncobiome and Crimson

Fondation Carrefour

Institut National du Cancer (INCa)

Institut Universitaire de France

LabEx Immuno-Oncology (ANR-18-IDEX-0001)

Cancer Research ASPIRE Award from the Mark Foundation

RHU Immunolife

Seerave Foundation

SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)

SIRIC Cancer Research and Personalized Medicine (CARPEM)

Fondation pour la Recherche Médicale (FRM)



The original article is available at

Published Citation

Vitale I. et al. Apoptotic cell death in disease - current understanding of the NCCD 2023. Cell Death Differ. 2023;30(5):1097-1154.

Publication Date

26 April 2023

PubMed ID



  • Physiology and Medical Physics


Nature Publishing Group


  • Accepted Version (Postprint)