Application of permeation enhancers in oral delivery of macromolecules: an update
journal contributionposted on 16.07.2021, 16:07 by Sam Maher, David J Brayden, Luca Casettari, Lisbeth Illum
The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broadened to encompass a role for nanoparticle approaches, PEs represent a key constituent of conventional oral formulations that have progressed to clinical testing. In this review, we highlight promising PEs in early development, summarize the current state of the art, and highlight challenges to the translation of PE-based delivery systems into safe and effective oral dosage forms for patients.
Science Foundation Ireland Centre for Medical Devices (CURAM) under grant agreement 13/RC/20173.
CommentsThe original article is available at https://www.mdpi.com
Published CitationMaher S, Brayden DJ, Casettari L, Illum L. Application of permeation enhancers in oral delivery of macromolecules: an update. Pharmaceutics. 2019;11(1):41.
Publication Date19 January 2019
- School of Pharmacy and Biomolecular Sciences
- Chemistry and Pharmaceutical Sciences
- Published Version (Version of Record)