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Application of permeation enhancers in oral delivery of macromolecules: an update

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journal contribution
posted on 16.07.2021, 16:07 by Sam Maher, David J Brayden, Luca Casettari, Lisbeth Illum
The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broadened to encompass a role for nanoparticle approaches, PEs represent a key constituent of conventional oral formulations that have progressed to clinical testing. In this review, we highlight promising PEs in early development, summarize the current state of the art, and highlight challenges to the translation of PE-based delivery systems into safe and effective oral dosage forms for patients.

Funding

Science Foundation Ireland Centre for Medical Devices (CURAM) under grant agreement 13/RC/20173.

History

Comments

The original article is available at https://www.mdpi.com

Published Citation

Maher S, Brayden DJ, Casettari L, Illum L. Application of permeation enhancers in oral delivery of macromolecules: an update. Pharmaceutics. 2019;11(1):41.

Publication Date

19 January 2019

PubMed ID

30669434

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Chemistry and Pharmaceutical Sciences

Publisher

MDPI AG

Version

  • Published Version (Version of Record)