Royal College of Surgeons in Ireland
Application of Permeation Enhancers in Oral Delivery....pdf (982.83 kB)

Application of permeation enhancers in oral delivery of macromolecules: an update

Download (982.83 kB)
journal contribution
posted on 2021-07-16, 16:07 authored by Sam MaherSam Maher, David J Brayden, Luca Casettari, Lisbeth Illum
The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broadened to encompass a role for nanoparticle approaches, PEs represent a key constituent of conventional oral formulations that have progressed to clinical testing. In this review, we highlight promising PEs in early development, summarize the current state of the art, and highlight challenges to the translation of PE-based delivery systems into safe and effective oral dosage forms for patients.


Science Foundation Ireland Centre for Medical Devices (CURAM) under grant agreement 13/RC/20173.



The original article is available at

Published Citation

Maher S, Brayden DJ, Casettari L, Illum L. Application of permeation enhancers in oral delivery of macromolecules: an update. Pharmaceutics. 2019;11(1):41.

Publication Date

19 January 2019

PubMed ID



  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Chemistry and Pharmaceutical Sciences




  • Published Version (Version of Record)