Royal College of Surgeons in Ireland
Biochemically recurrent prostate cancer. Rationalisation of approach to imaging.pdf (651.97 kB)

Biochemically recurrent prostate cancer: rationalisation of the approach to imaging

Download (651.97 kB)
journal contribution
posted on 2023-05-10, 16:42 authored by Hayley Briody, M Sheehan, M Hanley, B O’Neill, R Dunne, MJ Lee, M Morrin

Aim: To assess the utility of magnetic resonance imaging (MRI) in addition to the additive benefit of the conventional imaging techniques, computed tomography (CT) and nuclear medicine (NM) bone scintigraphy, for investigation of biochemical recurrence (BCR) post-prostatectomy where access to prostate specific membrane antigen (PSMA) positron-emission tomography (PET)-CT is challenging.

Materials and methods: Relevant imaging over a 5-year period was reviewed. Ethical approval was granted by the internal review board. All patients with suspected BCR, defined as a PSA ≥0.2 ng/ml on two separate occasions, underwent a retrospective imaging review. This was performed on PACS archive search database in a single centre using search terms "PSA" and "prostatectomy" in the three imaging methods; MRI, CT, and NM bone scintigraphy. All PSMA PET CT performed were recorded.

Results: One hundred and eighty-five patients were identified. Patients with an MRI pelvis that demonstrated distant metastases (i.e., pelvic bone metastases or lymph node involvement more cranial to the bifurcation of the common iliac arteries) were more likely to have a positive CT and/or NM bone scintigraphy. The Pearson correlation coefficient between the findings of M1 disease at MRI pelvis and the presence of distant metastases at CT thorax, abdomen, pelvis and NM bone scintigraphy was calculated at 0.81 (p<0.01) and 0.91 (p<0.01) respectively.

Conclusion: An imaging strategy based on risk stratification and technique-specific selection criteria leads to more appropriate use of resources, and in turn, increases the yield of conventional imaging methods. MRI prostate findings can be used to predict the additive value of CT/NM bone scintigraphy allowing a more streamlined approach to their use.



The original article is available at

Published Citation

Briody H. et al. Biochemically recurrent prostate cancer: rationalisation of the approach to imaging. Clin Radiol. 2023;78(7):518-524.

Publication Date

4 April 2023

PubMed ID



  • Beaumont Hospital
  • Medicine


Blackwell Scientific Publications Ltd


  • Accepted Version (Postprint)