Royal College of Surgeons in Ireland
Biofilm and the role of the ica operon and aap in Staphylococcus.pdf (77.82 kB)

Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis.

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Version 2 2021-12-17, 17:51
Version 1 2019-11-22, 16:36
journal contribution
posted on 2021-12-17, 17:51 authored by Niall StevensNiall Stevens, M Tharmabala, Tracey DillaneTracey Dillane, Catherine GreeneCatherine Greene, James P. O'Gara, Hilary HumphreysHilary Humphreys
Fifty-five Staphylococcus epidermidis isolates, classified as contaminants or causing device-related meningitis, from external ventricular drain (EVD) and non-EVD cerebrospinal fluid specimens were characterized. Thirty-three of 42 (78.6%) meningitis isolates were PCR-positive for ica and aap, known determinants of polysaccharide- and protein-mediated biofilm production, whereas five of 13 (38.5%) contaminants were ica- and aap-negative; 71.4% of meningitis isolates and 84.6% of contaminants produced biofilm. ica+aap+ meningitis isolates produced more biofilm than ica+aap- isolates (p 0.0020). ica+aap- isolates did not produce more biofilm than ica-aap+ isolates (p 0.4368). Apparently, ica and aap are associated with biofilm production in S. epidermidis device-related meningitis isolates.



Published in Clinical Microbiology and Infection 2008 Jul;14(7):719-22. The definitive version is available at

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  • Beaumont Hospital
  • Clinical Microbiology
  • Medicine