Royal College of Surgeons in Ireland
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Bioinks and biofabrication techniques for biosensors development: a review

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posted on 2024-11-25, 17:49 authored by Róisín Byrne, Amanda Carrico, Mariagrazia Lettieri, Athira K Rajan, Robert J Forster, Loanda R Cumba

3D bioprinting technologies and bioink development are enabling significant advances in miniaturized and integrated biosensors. For example, bioreceptors can be immobilized within a porous 3D structure to significantly amplify the signal, while biocompatible and mechanically flexible systems uniquely enable wearable chem- and bio-sensors. This advancement is accelerating translation by enabling the production of high performance, reproducible, and flexible analytical devices. The formulation of the bioink plays a crucial role in determining the bio-functionality of the resulting printed structures, e.g., the porosity that allows the analyte to diffuse through the 3D structure, the affinity and avidity of the receptors, etc. This review explores the next generation of advanced bioinks for biosensor development and provides insights into the latest cutting-edge bioprinting technologies. The bioprinting methods available for biosensor fabrication including inkjet, extrusion, and laser-based bioprinting, are discussed. The advantages and limitations of each method are analysed, and recent advancements in bioprinting technologies are presented. The review then delves into the properties of advanced bioinks, such as biocompatibility, printability, stability, and applicability. Different types of advanced bioinks are explored, including multicomponent, stimuli-responsive, and conductive bioinks. Finally, the next generation of bioinks for biosensors is considered, identifying possible new opportunities and challenges. Overall, this literature review highlights the combined importance of bioink formulation and bioprinting methods for the development of high-performance analytical biosensors 

Funding

MultiMAT Development of Functional 3D printable advanced (bio)inks.

Science Foundation Ireland

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History

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The original article is available at https://www.sciencedirect.com/

Published Citation

Byrne R. et al. Bioinks and biofabrication techniques for biosensors development: a review. Mater Today Bio. 2024;28:101185.

Publication Date

5 August 2024

PubMed ID

39205870

Department/Unit

  • FutureNeuro Centre

Publisher

Elsevier

Version

  • Published Version (Version of Record)