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Biomaterial and therapeutic approaches for the manipulation of macrophage phenotype in peripheral and central nerve repair

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journal contribution
posted on 18.01.2022, 15:25 authored by Adrian DervanAdrian Dervan, Antonio Franchi, Francisco R Almeida-Gonzalez, Jennifer DowlingJennifer Dowling, Ohemaa B Kwakyi, Fergal O'BrienFergal O'Brien, Claire McCoyClaire McCoy, Alan HibbittsAlan Hibbitts
Injury to the peripheral or central nervous systems often results in extensive loss of motor and sensory function that can greatly diminish quality of life. In both cases, macrophage infiltration into the injury site plays an integral role in the host tissue inflammatory response. In particular, the temporally related transition of macrophage phenotype between the M1/M2 inflammatory/repair states is critical for successful tissue repair. In recent years, biomaterial implants have emerged as a novel approach to bridge lesion sites and provide a growth-inductive environment for regenerating axons. This has more recently seen these two areas of research increasingly intersecting in the creation of ‘immune-modulatory’ biomaterials. These synthetic or naturally derived materials are fabricated to drive macrophages towards a pro-repair phenotype. This review considers the macrophage-mediated inflammatory events that occur following nervous tissue injury and outlines the latest developments in biomaterial-based strategies to influence macrophage phenotype and enhance repair.

Funding

Science Foundation Ireland (SFI) SFI16/ FRL/3855

SFI and the Advanced Materials and Bioengineering Research (AMBER) Centre (Project No. TP27-1846A1 and 12/RC/2278)

Enterprise Ireland (CF-2020-1336-P)

Irish Rugby Football Union Charitable Trust (IRFU-CT)

AMBER Centre through Science Foundation Ireland (SFI/12/RC/2278)

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Dervan A. et al. Biomaterial and therapeutic approaches for the manipulation of macrophage phenotype in peripheral and central nerve repair. Pharmaceutics. 2021;13(12):2161

Publication Date

15 December 2021

PubMed ID

34959446

Department/Unit

  • Amber (Advanced Material & Bioengineering Research) Centre
  • Anatomy and Regenerative Medicine
  • FutureNeuro Centre
  • School of Medicine
  • School of Pharmacy and Biomolecular Sciences
  • Tissue Engineering Research Group (TERG)
  • Undergraduate Research

Research Area

  • Chemistry and Pharmaceutical Sciences
  • Immunity, Infection and Inflammation
  • Respiratory Medicine
  • Biomaterials and Regenerative Medicine
  • Neurological and Psychiatric Disorders

Publisher

MDPI AG

Version

  • Published Version (Version of Record)