10.1158@0008-5472.CAN-20-0291.pdf (1.37 MB)

Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.

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journal contribution
posted on 16.12.2020, 15:17 by Manuel Valiente, Amanda ED Van Swearingen, Carey K Anders, Amos Bairoch, Adrienne Boire, Paula D Bos, Diana M Cittelly, Neta Erez, Gino B Ferraro, Dai Fukumura, Brunilde Gril, Meenhard Herlyn, Sheri L Holmen, Rakesh K Jain, Johanna A Joyce, Mihaela Lorger, Joan Massague, Josh Neman, Nicola R Sibson, Patricia S Steeg, Frits Thorsen, Leonie Young, Damir Vareslija, Adina Vultur, Frances Weis-Garcia, Frank Winkler
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect in the past due to its untreatable nature and invariable lethality, nowadays, limited but encouraging examples have questioned this statement, making it more attractive for basic and clinical researchers. Evidences of its own biological identity (i.e., specific microenvironment) and particular therapeutic requirements (i.e., presence of blood-brain barrier, blood-tumor barrier, molecular differences with the primary tumor) are thought to be critical aspects that must be functionally exploited using preclinical models. We present the coordinated effort of 19 laboratories to compile comprehensive information related to brain metastasis experimental models. Each laboratory has provided details on the cancer cell lines they have generated or characterized as being capable of forming metastatic colonies in the brain, as well as principle methodologies of brain metastasis research. The Brain Metastasis Cell Lines Panel (BrMPanel) represents the first of its class and includes information about the cell line, how tropism to the brain was established, and the behavior of each model in vivo. These and other aspects described are intended to assist investigators in choosing the most suitable cell line for research on brain metastasis. The main goal of this effort is to facilitate research on this unmet clinical need, to improve models through a collaborative environment, and to promote the exchange of information on these valuable resources.

Funding

MINECO grants MINECO-Retos SAF2017-89643-R

Bristol-Myers Squibb-Melanoma Research Alliance Young Investigator Award 2017 (498103)

Fundacion Ramon Areces (CIVP19S8163)

Worldwide Cancer Research (19-0177)

H2020-FETOPEN (828972)

Clinic and Laboratory Integration Program CRI Award 2018 (54545)

AECC Coordinated Translational Groups 2017 (GCTRA16015SEOA)

LAB AECC 2019 (LABAE19002VALI)

METAvivor Inc.

Susan G Komen Career Catalyst Grant (CCR18548205)

Susan G Komen Career Catalyst Grant (CCR15332673)

NIH/NCI (1R01CA223544-01A1)

Department of Defense BCRP (BC141728)

Cancer Research UK (C5255/A15935), R37 CA227984, DoD BCRP BC141980

Metavivor Research Foundation, in collaboration with the Brain Tumor Biorepository at the University of Colorado, PO1 CA114046

Dr. Miriam and Sheldon G. Adelson Medical Research

Harvard Ludwig Center, MIT/HMS Bridge grant

National Cancer Institute Outstanding Investigator Award (R35CA197743)

Susan G. Komen Foundation (PDF15331878)

Breast Cancer Research Foundation

Cancer Research UK iMAXT Consortium

Ludwig Institute for Cancer Research

Swiss Cancer League and the Swiss Bridge Award

NCI (R01CA121118)

Melanoma Research Alliance (347651)

Ramon y Cajal Investigator (RYC-2013-13365)

EMBO YIP (4053)

History

Comments

The original article is available at https://cancerres.aacrjournals.org/

Published Citation

Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massague J, Neman J, Sibson NR, Steeg PS, Thorsen F, Young LS, Varešlija D, Vultur A, Weis-Garcia F, Winkler F. Brain metastasis cell lines panel: a public resource of organotropic cell lines. Cancer Research. 2020;80(20):4314-4323.

Publication Date

8 July 2020

PubMed ID

32641416

Department/Unit

  • Surgery

Research Area

  • Cancer
  • Surgical Science and Practice

Publisher

American Association for Cancer Research (AACR)

Version

  • Accepted Version (Postprint)