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COVID-19 associated invasive pulmonary aspergillosis: diagnostic and therapeutic challenges

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posted on 15.03.2022, 17:01 authored by Aia Mohamed, Thomas R Rogers, Alida TalentoAlida Talento
Aspergillus co-infection in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, leading to acute respiratory distress syndrome, has recently been reported. To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. Importantly, there is currently no agreed case definition of COVID-19 associated invasive pulmonary aspergillosis (CAPA) that could aid in the early detection of this co-infection. Additionally, with the global emergence of triazole resistance, we emphasize the importance of antifungal susceptibility testing in order to ensure appropriate antifungal therapy. Herein is a review of 38 published CAPA cases, which highlights the diagnostic and therapeutic challenges posed by this novel fungal co-infection.

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Mohamed A, Rogers TR, Talento AF. COVID-19 associated invasive pulmonary aspergillosis: diagnostic and therapeutic challenges J Fungi (Basel). 2020;6(3):115.

Publication Date

22 July 2020

PubMed ID

32707965

Department/Unit

  • Clinical Microbiology

Publisher

MDPI

Version

  • Published Version (Version of Record)