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COVID-19 biomarkers for severity mapped to polycystic ovary syndrome

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journal contribution
posted on 16.12.2021, 15:10 by Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E Butler

Large scale multi-omics analysis has identified significant differences in the biomarkers between COVID-19 disease and control subjects. These protein panels target biological processes involved in vessel damage, platelet degranulation, the coagulation cascade and the acute phase response, with greater protein changes dependent on the COVID-19 severity. However, it is observed that in metabolic conditions such as polycystic ovary syndrome expressed proteins differ compared to control women and PCOS patients have increased platelet aggregation and decreased plasma fibrinolytic activity, resulting in a prothrombotic propensity, with elevated coagulation markers. Therefore, any biomarkers reflecting COVID-19 disease and its severity would necessarily have to be independent of differentially-expressed proteins relating to other conditions; therefore, this proteomic analysis was undertaken in women with and without PCOS to compare with the proteomic biomarkers recently described in COVID-19 using shotgun proteomics followed by parallel reaction monitoring.


History

Comments

The original article is available at https://translational-medicine.biomedcentral.com This article has an Erratum that can be found at https://doi.org/10.1186/s12967-021-02782-w Moin ASM, Sathyapalan T, Atkin SL, Butler AE. Correction to: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome. J Transl Med. 2021;19(1):106.

Published Citation

Moin ASM, Sathyapalan T, Atkin SL, Butler AE. COVID-19 biomarkers for severity mapped to polycystic ovary syndrome. J Transl Med. 2020;18(1):490.

Publication Date

22 December 2020

PubMed ID

33353554

Department/Unit

  • RCSI Bahrain

Publisher

BioMed Central

Version

  • Published Version (Version of Record)