Cardiac Progenitor Cells from Stem Cells.....pdf (1.12 MB)
Download file

Cardiac progenitor cells from stem cells: learning from genetics and biomaterials

Download (1.12 MB)
journal contribution
posted on 16.12.2021, 12:17 authored by Sara Barreto, Leonie Hamel, Teresa Schiatti, Ying Yang, Vinoj George
Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all the cardiac lineages. These cells offer a significant shift in paradigm over the use of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes owing to the latter's inability to recapitulate mature features of a native myocardium, limiting their translational applications. The iPSCs and direct reprogramming of somatic cells have been attempted to produce CPCs and, in this process, a variety of chemical and/or genetic factors have been evaluated for their ability to generate, expand, and maintain CPCs in vitro. However, the precise stoichiometry and spatiotemporal activity of these factors and the genetic interplay during embryonic CPC development remain challenging to reproduce in culture, in terms of efficiency, numbers, and translational potential. Recent advances in biomaterials to mimic the native cardiac microenvironment have shown promise to influence CPC regenerative functions, while being capable of integrating with host tissue. This review highlights recent developments and limitations in the generation and use of CPCs from stem cells, and the trends that influence the direction of research to promote better application of CPCs.

Funding

Engineering and Physical Sciences Research Council (EPSRC), UK, grant number EP/L015072/1

History

Comments

The original article is available at https://www.mdpi.com

Published Citation

Barreto S, Hamel L, Schiatti T, Yang Y, George V. Cardiac progenitor cells from stem cells: learning from genetics and biomaterials. Cells. 2019;8(12):1536

Publication Date

28 November 2019

PubMed ID

31795206

Department/Unit

  • RCSI Bahrain

Publisher

MDPI

Version

  • Published Version (Version of Record)