Royal College of Surgeons in Ireland
Cardiovascular Functions of EnaVASP Proteins Past, Present and Beyond.pdf (8.65 MB)

Cardiovascular functions of Ena/VASP proteins: past, present and beyond

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journal contribution
posted on 2023-08-10, 10:29 authored by Peter M Benz, Timo Frömel, Hebatullah Laban, Joana Zink, Lea Ulrich, Dieter Groneberg, Reinier A Boon, Philip Poley, Thomas Renne, Cor de Wit, Ingrid Fleming

Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms. 


Deutsche Forschungsgemeinschaft (SFB 834/A8 & SFB 834/A5)

German Center for Cardiovascular Research (DZHK B14-028 SE)



The original article is available at

Published Citation

Benz PM, et al. Cardiovascular functions of Ena/VASP proteins: past, present and beyond. Cells. 2023;12(13):1740.

Publication Date

28 June 2023

PubMed ID



  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences


MDPI (Basel, Switzerland)


  • Published Version (Version of Record)