Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes.pdf (227.46 kB)
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Characterizing and exploiting tumor microenvironments to optimize treatment outcomes

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journal contribution
posted on 30.05.2022, 16:31 authored by Emma H Allott, Kellie Dean, Tracy RobsonTracy Robson, Claire Meaney

Our understanding of cancer initiation, progression, and treatment is continually pro-gressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments.

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Comments

The original article is available at https://www.mdpi.com/

Published Citation

Allott EH, Dean K, Robson T, Meaney C. Characterizing and exploiting tumor microenvironments to optimize treatment outcomes. Cancers (Basel). 2021;13(22):5752

Publication Date

17 November 2021

PubMed ID

34830906

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Cancer
  • Vascular Biology
  • Immunity, Infection and Inflammation

Publisher

MDPI AG

Version

  • Published Version (Version of Record)