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Chemical composition and antimicrobial activity of Congea tomentosa, an ethnomedicinal plant from Bangladesh.

journal contribution
posted on 13.01.2021, 10:10 by Mohammad Omar Faruque, Umme Ruman Ankhi, M Kamaruzzaman, James Barlow, Bo Zhou, Ji Hao, Xinzhou Yang, Xuebo Hu
Congea tomentosa Roxb. (CT) is used as a medicinal plant by indigenous peoples of Bangladesh, but to date remains largely unexplored from a phytochemical or pharmacological perspective. In this study, the extracts of leaves, stems and flowers of CT were tested for antimicrobial activity using the agar well diffusion and micro-dilution methods. Compared with leaf and flower extracts, the crude stem extract was the most effective against the tested microorganisms. Therefore, the crude stem extract was further subjected to sequential fractionation, with the petroleum ether and ethyl acetate extracts proving the most active against tested microorganisms. Using GC–MS analysis, 10 compounds were identified within the petroleum ether extract, all of which are known to the literature, and some/all of which may have contributed to the observed antimicrobial properties. Additionally, two compounds (β-amyrin and stigmasterol) were isolated from the ethyl acetate fraction and identified using mass spectrometry and NMR spectroscopy. Compound 2 (stigmasterol) displayed promising antimicrobial activity against tested microorganisms. Despite the ethnobotanical importance of CT, this work represents the first scientific report supporting its traditional use, and demonstrates that both the stem extract of this ethnomedicinal plant and the isolated compound 2 (stigmasterol) may offer potential as antimicrobials.

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The original article is available at www.sciencedirect.com

Published Citation

Faruque MO, Ankhi UR, Kamaruzzaman, M, Barlow JW, Zhou B, Hao J, Yang X, Hu X. Chemical composition and antimicrobial activity of Congea tomentosa, an ethnomedicinal plant from Bangladesh. Industrial Crops & Products. 2019;141:111745

Publication Date

26 Sept 2019

Department/Unit

  • Chemistry

Research Area

  • Chemistry and Pharmaceutical Sciences

Publisher

Elsevier BV

Version

  • Accepted Version (Postprint)

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