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Circadian rhythm in systemic autoimmune conditions: potential of chrono-immunology in clinical practice: a narrative review

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posted on 2023-08-25, 15:46 authored by Wireko Andrew Awuah, Helen Huang, Jacob Kalmanovich, Aashna Mehta, Tatiana Mikhailova, Jyi Cheng Ng, Toufik Abdul-Rahman, Favour Tope Adebusoye, Joecelyn Kirani Tan, Karl Kamanousa, Tomas Ferreira, Sakshi Roy, Mrinmoy Kundu, Rohan Yarlagadda, Nobendu Mukerjee, Athanasios Alexiou, Marios Papadakis

The circadian rhythm (CR) is a fundamental biological process regulated by the Earth's rotation and solar cycles. It plays a critical role in various bodily functions, and its dysregulation can have systemic effects. These effects impact metabolism, redox homeostasis, cell cycle regulation, gut microbiota, cognition, and immune response. Immune mediators, cycle proteins, and hormones exhibit circadian oscillations, supporting optimal immune function and defence against pathogens. Sleep deprivation and disruptions challenge the regulatory mechanisms, making immune responses vulnerable. Altered CR pathways have been implicated in diseases such as diabetes, neurological conditions, and systemic autoimmune diseases (SADs). SADs involve abnormal immune responses to self-antigens, with genetic and environmental factors disrupting self-tolerance and contributing to conditions like Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Inflammatory Myositis. Dysregulated CR may lead to increased production of pro-inflammatory cytokines, contributing to the systemic responses observed in SADs. Sleep disturbances significantly impact the quality of life of patients with SADs; however, they are often overlooked. The relationship between sleep and autoimmune conditions, whether causal or consequential to CR dysregulation, remains unclear. Chrono-immunology investigates the role of CR in immunity, offering potential for targeted therapies in autoimmune conditions. This paper provides an overview of the connections between sleep and autoimmune conditions, highlighting the importance of recognizing sleep disturbances in SADs and the need for further research into the complex relationship between the CR and autoimmune diseases. 

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The original article is available at https://journals.lww.com

Published Citation

Awuah WA, et al. Circadian rhythm in systemic autoimmune conditions: potential of chrono-immunology in clinical practice: a narrative review. Medicine (Baltimore). 2023;102(32):e34614

Publication Date

11 August 2023

PubMed ID

37565922

Department/Unit

  • Undergraduate Research

Publisher

Wolters Kluwer Health, Inc.

Version

  • Published Version (Version of Record)

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