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Circulating miR-330-3p in late pregnancy is associated with pregnancy outcomes among lean women with GDM.

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journal contribution
posted on 07.01.2021, 14:54 by Shona Pfeiffer, Begona Sanchez-Lechuga, Paul Donovan, Luise Halang, Jochen Prehn, Antonio Campos-Caro, Maria M. Byrne, Cristina Lopez-Tinoco
Gestational Diabetes Mellitus (GDM) is characterised by insulin resistance accompanied by reduced beta-cell compensation to increased insulin demand, typically observed in the second and third trimester and associated with adverse pregnancy outcomes. There is a need for a biomarker that can accurately monitor status and predict outcome in GDM, reducing foetal-maternal morbidity and mortality risks. To this end, circulating microRNAs (miRNAs) present themselves as promising candidates, stably expressed in serum and known to play crucial roles in regulation of glucose metabolism. We analysed circulating miRNA profiles in a cohort of GDM patients (n = 31) and nondiabetic controls (n = 29) during the third trimester for miRNA associated with insulin-secretory defects and glucose homeostasis. We identified miR-330-3p as being significantly upregulated in lean women with GDM compared to nondiabetic controls. Furthermore, increased levels of miR-330-3p were associated with better response to treatment (diet vs. insulin), with lower levels associated with exogenous insulin requirement. We observed miR-330-3p to be significantly related to the percentage of caesarean deliveries, with miR-330-3p expression significantly higher in spontaneously delivered GDM patients. We report this strong novel association of circulating miR-330-3p with risk of primary caesarean delivery as a pregnancy outcome linked with poor maternal glycaemic control, strengthening the growing body of evidence for roles of diabetes-associated miRNAs in glucose homeostasis and adaptation to the complex changes related to pregnancy.

Funding

Ministry of Education, Culture and Sport of Spain under the program "Jose Castillejo: Subprograma Estatal de Movilidad, del Plan Estatal de I+D+I (CAS 18/00190)"

Health Research Fund (FIS) of the Ministry of Health of Spain through the project PI16/00370 (co-funded by European Regional Development Fund, ERDF)

Investigator Award from Science Foundation Ireland (14/IA/2582)

History

Comments

The original article is available at www.nature.com

Published Citation

Pfeiffer S, Sánchez-Lechuga B, Donovan P, Halang L, Prehn JHM, Campos-Caro A, Byrne MM, López-Tinoco C. Circulating miR-330-3p in late pregnancy is associated with pregnancy outcomes among lean women with GDM. Sci Rep. 2020;10(1):908.

Publication Date

22 Jan 2020

PubMed ID

31969632

Department/Unit

  • Centre for Systems Medicine
  • Physiology and Medical Physics

Research Area

  • Neurological and Psychiatric Disorders
  • Cancer

Publisher

Springer Science and Business Media LLC

Version

  • Published Version (Version of Record)

Licence

Exports