posted on 2021-05-24, 10:34authored byShaon Sengupta, Louise Ince, Francesca Sartor, Helene Borrmann, Xiaodong Zhuang, Amruta Naik, Annie CurtisAnnie Curtis, Jane A McKeating
Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.
Funding
NHLBI-K08HL132053
Wellcome Trust DPhil program in Infection, Immunology and Translational Medicine
“Life” initiative of the Volkswagen Foundation
Wellcome Trust IA 200838/Z/16/Z
MRC project grant MR/R022011/1
Science Foundation Ireland Career Development Award (17/CDA/4688)
Irish Research Council Laureate Award (IRCLA/2017/110)
Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant number: 2018-I2M-2- 002)
History
Comments
The original article is available at https://journals.sagepub.com
Published Citation
Sengupta S, Ince L, Sartor F, Borrmann H, Zhuang X, Naik A, Curtis A, McKeating JA. Clocks, viruses, and immunity: lessons for the COVID-19 pandemic. Journal of Biological Rhythms. 2021;36(1):23-34.