Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.
journal contributionposted on 2022-04-05, 14:56 authored by Caroline CurtinCaroline Curtin, Erica G. Tierney, Kevin McSorley, Sally-Ann CryanSally-Ann Cryan, Garry DuffyGarry Duffy, Fergal O'BrienFergal O'Brien
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.
European Research Council. Science Foundation Ireland
CommentsThe original article is available at http://onlinelibrary.wiley.com
Published CitationCurtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ. Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold. Advanced Healthcare Materials. 2015;4(2):223-7
- Amber (Advanced Material & Bioengineering Research) Centre
- Anatomy and Regenerative Medicine
- Tissue Engineering Research Group (TERG)