Combinatorial gene therapy accelerates bone regeneration: non-vir.pdf (888.84 kB)
Download fileCombinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.
journal contribution
posted on 2022-04-05, 14:56 authored by Caroline CurtinCaroline Curtin, Erica G. Tierney, Kevin McSorley, Sally-Ann CryanSally-Ann Cryan, Garry DuffyGarry Duffy, Fergal O'BrienFergal O'BrienVascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.
Funding
European Research Council. Science Foundation Ireland
History
Comments
The original article is available at http://onlinelibrary.wiley.comPublished Citation
Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ. Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold. Advanced Healthcare Materials. 2015;4(2):223-7Publication Date
2015-01-28External DOI
PubMed ID
25125073Department/Unit
- Amber (Advanced Material & Bioengineering Research) Centre
- Anatomy and Regenerative Medicine
- Tissue Engineering Research Group (TERG)