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Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.

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posted on 05.04.2022, 14:56 by Caroline CurtinCaroline Curtin, Erica G. Tierney, Kevin McSorley, Sally-Ann CryanSally-Ann Cryan, Garry DuffyGarry Duffy, Fergal O'BrienFergal O'Brien

Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.

Funding

European Research Council. Science Foundation Ireland

History

Comments

The original article is available at http://onlinelibrary.wiley.com

Published Citation

Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ. Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold. Advanced Healthcare Materials. 2015;4(2):223-7

Publication Date

2015-01-28

PubMed ID

25125073

Department/Unit

  • Amber (Advanced Material & Bioengineering Research) Centre
  • Anatomy and Regenerative Medicine
  • Tissue Engineering Research Group (TERG)