Comparison of severe viral pneumonia caused by SARS-CoV-2 and other respiratory viruses among Malaysian children during the COVID-19 pandemic
journal contributionposted on 2022-06-01, 15:46 authored by David Chun-Ern Ng, Kah Kee Tan, Grace Sieng Sing Ting, Chin Ling, Nur Fadzreena Binti Fadzilah, Shir Fong Tan, Thayasheri Subramaniam, Nur Emylia Binti Zailanalhuddin, Hui Yi Lim, Suhaila Binti Baharuddin, Yee Lean Lee, Airena Mohamad Nor, Erwin Jiayuan Khoo
Objectives: We described the etiology of severe pneumonia in children during the height of the COVID-19 pandemic in Malaysia and compared the clinical features of severe SARS-CoV-2 to other respiratory viruses.
Methods: This retrospective study included all children aged 12 years and below hospitalized with severe pneumonia in Negeri Sembilan, Malaysia, between 1 April 2021 and 31 October 2021. We extracted demographic and clinical data and used logistic regression to examine risk factors associated with severe SARS-CoV-2 or other viral pneumonia.
Results: A total of 111 children were included. The median age was 15 months. Human rhinovirus/enterovirus, SARS-CoV-2 and respiratory syncytial virus were the most common etiology of severe pneumonia. Codetection of >1 viral pathogen was present in 14 (12.6%) patients. Children with severe COVID-19 presented early in the course of illness and had lower rates of pediatric intensive care admission. The presence of sick contact with an adult was a predictor for SARS-CoV-2, whereas adventitious breath sounds were predictive of other respiratory viruses.
Conclusions: The etiology of severe pneumonia in children evolved with the epidemic curve of COVID-19 and school closures. Children with severe pneumonia due to SARS-CoV-2 experienced a milder clinical course when compared to other respiratory viruses.
Open access publication fees are funded by the International Medical University
CommentsThe original article is available at https://www.frontiersin.org/
Published CitationNg DC, et al. Comparison of severe viral pneumonia caused by SARS-CoV-2 and other respiratory viruses among Malaysian children during the COVID-19 pandemic. Front Pediatr. 2022;10:865099.
Publication Date25 April 2022
PublisherFrontiers Media S.A.
- Published Version (Version of Record)