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Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions

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journal contribution
posted on 19.01.2022, 17:50 authored by Viktorija JuricViktorija Juric, Brona MurphyBrona Murphy

Cyclin-dependent kinases (CDKs) are important regulatory enzymes in the normal physiological processes that drive cell-cycle transitions and regulate transcription. Virtually all cancers harbour genomic alterations that lead to the constitutive activation of CDKs, resulting in the proliferation of cancer cells. CDK inhibitors (CKIs) are currently in clinical use for the treatment of breast cancer, combined with endocrine therapy. In this review, we describe the potential of CKIs for the treatment of cancer with specific focus on glioblastoma (GBM), the most common and aggressive primary brain tumour in adults. Despite intense effort to combat GBM with surgery, radiation and temozolomide chemotherapy, the median survival for patients is 15 months and the majority of patients experience disease recurrence within 6-8 months of treatment onset. Novel therapeutic approaches are urgently needed for both newly diagnosed and recurrent GBM patients. In this review, we summarise the current preclinical and clinical findings emphasising that CKIs could represent an exciting novel approach for GBM treatment.

Funding

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement #766069 (GLIO-TRAIN)

History

Comments

The original article is available at https://cdrjournal.com/

Published Citation

Juric V, Murphy B. Cyclin-dependent kinase inhibitors in brain cancer: current state and future directions. Cancer Drug Resist. 2020;3(1):48-62

Publication Date

19 March 2020

PubMed ID

35582046

Department/Unit

  • Physiology and Medical Physics

Research Area

  • Cancer

Publisher

OAE Publishing Inc.

Version

  • Published Version (Version of Record)