Royal College of Surgeons in Ireland
Delays in the stroke thrombolysis pathway--identifying areas for.pdf (469.33 kB)

Delays in the stroke thrombolysis pathway--identifying areas for improvement.

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Version 2 2021-09-16, 09:05
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journal contribution
posted on 2021-09-16, 09:05 authored by Linda BrewerLinda Brewer, Chinedum Arize, Joan McCormack, David WilliamsDavid Williams

Despite international consensus on the benefits of thrombolysis for ischaemic stroke (IS), it remains underused. Guidelines now recommend a door-to-needle time of 60 minutes. We reviewed the rate and timeliness of thrombolysis for IS at our hospital. 323 stroke patients presented between January 2011 and April 2012.Thirty patients (10.6% of IS) were thrombolysed, mean age was 68.5 years (42 to 88) and 19 patients (63%) were male. Thirty-six patients (12.7% of IS) were not thrombolysed despite arriving within the time-window and symptom resolution was the commonest reason (15 patients; 42%). Despite most thrombolysed patients (42%) presenting to the Emergency Department during daytime working hours, there were delays at each step of the acute care pathway. The mean time for stroke team review was 23 minutes (5-50). The mean door-to-CT and the door-to-needle times were 60 minutes (25-95) and 92 minutes (46-130) respectively. In parallel with national stroke incentives, local audit can highlight barriers to uptake and efficiency within thrombolysis services.


T Farrell, Charitable Infirmary Charitable Trust, The Association of Physicians of Great Britain and Ireland, Madeleine Farrell Charitable Bequest.



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Published Citation

Brewer L, Arize C, McCormack J, Williams D. Delays in the stroke thrombolysis pathway--identifying areas for improvement. Irish Medical Journal. 2014;107(5):143-6.

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  • Beaumont Hospital
  • Undergraduate Research