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Development and evaluation of a Multifrequency Ultrafast Doppler Spectral Analysis.....pdf (1.97 MB)

Development and evaluation of a Multifrequency Ultrafast Doppler Spectral Analysis (MFUDSA) algorithm for wall shear stress measurement: a simulation and in vitro study

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posted on 2023-07-19, 16:22 authored by Andrew J Malone, Seán Cournane, Izabela Naydenova, James F Meaney, Andrew J Fagan, Jacinta E Browne

Cardiovascular pathology is the leading cause of death and disability in the Western world, and current diagnostic testing usually evaluates the anatomy of the vessel to determine if the vessel contains blockages and plaques. However, there is a growing school of thought that other measures, such as wall shear stress, provide more useful information for earlier diagnosis and prediction of atherosclerotic related disease compared to pulsed-wave Doppler ultrasound, magnetic resonance angiography, or computed tomography angiography. A novel algorithm for quantifying wall shear stress (WSS) in atherosclerotic plaque using diagnostic ultrasound imaging, called Multifrequency ultrafast Doppler spectral analysis (MFUDSA), is presented. The development of this algorithm is presented, in addition to its optimisation using simulation studies and in-vitro experiments with flow phantoms approximating the early stages of cardiovascular disease. The presented algorithm is compared with commonly used WSS assessment methods, such as standard PW Doppler, Ultrafast Doppler, and Parabolic Doppler, as well as plane-wave Doppler. Compared to an equivalent processing architecture with one-dimensional Fourier analysis, the MFUDSA algorithm provided an increase in signal-to-noise ratio (SNR) by a factor of 4-8 and an increase in velocity resolution by a factor of 1.10-1.35. The results indicated that MFUDSA outperformed the others, with significant differences detected between the typical WSS values of moderate disease progression (p = 0.003) and severe disease progression (p = 0.001). The algorithm demonstrated an improved performance for the assessment of WSS and has potential to provide an earlier diagnosis of cardiovascular disease than current techniques allow. 

Funding

Technological University Dublin through the Fiosraigh scholarship 2015 program

Health Research Board Ireland

Irish Association of Physicists in Medicine through the Young Investigator Grant

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Malone AJ. et al. Development and evaluation of a Multifrequency Ultrafast Doppler Spectral Analysis (MFUDSA) algorithm for wall shear stress measurement: a simulation and in vitro study Diagnostics (Basel). 2023;13(11):1872.

Publication Date

27 May 2023

PubMed ID

37296724

Department/Unit

  • Anatomy and Regenerative Medicine
  • Tissue Engineering Research Group (TERG)

Publisher

MDPI

Version

  • Published Version (Version of Record)