Differing endometrial expression of calcium modulating transient receptor potential channels
Assisted reproductive techniques (ART) have increased the live birth success rate, but there is still a significant implantation failure rate. Epithelial cell calcium homeostasis is tightly regulated by mechanisms that include activation of the TRP channel superfamily of 9 families including TRPC (Canonical). TRPCs are located on the cell membrane and act as receptor-operated channels (ROC), whilst cytosolic localization of these channels indicates their role as store-operated channels (SOC): both ROCs and SOCs are key players in the regulation of intracellular calcium homeostasis. TRPC 1–4 and 6 expression in the bovine reproductive tract has been reported; these receptors exhibit hormone modulation and calcium dysregulation can lead to menstrual disturbances, suggesting that TRPC receptors may modulate calcium in the human endometrium and affect implantation and fertility.
CommentsThe original article is available at https://translational-medicine.biomedcentral.com/
Published CitationGhavideldarestani M, Butler AE, Atkin SL. Differing endometrial expression of calcium modulating transient receptor potential channels. J Transl Med. 2021;19(1):113.
Publication Date17 March 2021
- RCSI Bahrain
- Published Version (Version of Record)