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Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: biomarker response to hypoglycemia

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journal contribution
posted on 11.01.2022, 16:26 by Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L Atkin, Alexandra E Butler

Type 2 diabetes (T2D) is associated with high risk for acquiring SARSCov-2 infection, severe disease, acute respiratory distress syndrome and increased mortality. A recent publication reported five predictive COVID-19 severity markers that included CCL17 which was expressed in low levels in severe/critical patients at an early phase of infection; IFNλ, IL6, IP10, and CXCL9 values surged and then dropped suddenly before the development of severe disease requiring oxygen support. This suggested that CCL17 may be a useful first triage marker and the other reported proteins may help to predict severe disease onset.

History

Comments

The original article is available at https://www.metabolismjournal.com/

Published Citation

Moin ASM, Al-Qaissi A, Sathyapalan T, Atkin SL, Butler AE. Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: biomarker response to hypoglycemia. Metabolism. 2021;114:154417

Publication Date

3 November 2020

PubMed ID

33157081

Department/Unit

  • RCSI Bahrain

Publisher

Elsevier

Version

  • Accepted Version (Postprint)