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Dynamic epi-transcriptomic landscape mapping with disease progression in estrogen receptor-positive breast cancer

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posted on 2023-02-17, 08:02 authored by Stephen KeelanStephen Keelan, Mihaela OlaMihaela Ola, Sara Charmsaz, Sinead CocchigliaSinead Cocchiglia, Daniela OttavianiDaniela Ottaviani, Sean HickeySean Hickey, Siobhan Purcell, Fiona Bane, Aisling HegartyAisling Hegarty, Ben Doherty, Katherine SheehanKatherine Sheehan, Lance Hudson, Nicola CosgroveNicola Cosgrove, Benjamin Roux, Muriel Laine, Geoffrey Greene, Damir VareslijaDamir Vareslija, Arnold HillArnold Hill, Leonie YoungLeonie Young

The molecular determinants that drive breast cancer progression to metastasis are complex and partly controlled by nucleic acid epi-modifications. Although DNA-methyl modifications in breast cancer metastasis have been well described, there is limited understanding of the role of RNA methylation in advanced disease. This study aimed to provide an understanding on the role of the epi-transcriptome in estrogen receptor-positive (ER+) breast cancer progression to metastasis.

Funding

Breast Cancer Ireland (GR 14-0883) Science Foundation Ireland Investigator Award (12/IA/1294)

Science Foundation Ireland Frontiers for the Future Award (19/FFP/6443)

Science Foundation Ireland Strategic Partnership Programme, Precision Oncology Ireland (18/SPP/3522)

Breast Cancer NOW grant, Project (2018JulPR1094)

Breast Cancer NOW Fellowship Award (2019AugSF1310)

Irish Research Council Postgraduate Award (GOIPG/2020/361)

History

Comments

The original article is available at https://onlinelibrary.wiley.com/

Published Citation

Keelan S. et al. Dynamic epi-transcriptomic landscape mapping with disease progression in estrogen receptor-positive breast cancer. Cancer Commun (Lond). 2023;43(5):615-619

Publication Date

20 January 2023

External DOI

PubMed ID

36670046

Department/Unit

  • Beaumont Hospital
  • Pathology
  • School of Pharmacy and Biomolecular Sciences
  • Surgery

Publisher

BioMed Central

Version

  • Published Version (Version of Record)

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    Royal College of Surgeons in Ireland

    Categories

    Keywords

    breast cancer metastasisDynamic epi-transcriptomicestrogen receptor-positive (ER+)RNA methylationadvanced diseasemolecular determinantsDNA-methyl modificationsreceptor-positiveestrogenCancerEndocrinologyMedical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)

    Licence

    CC BY-NC-ND 4.0

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