Royal College of Surgeons in Ireland
Kerrigan et al Front Imm 2019.pdf (914.89 kB)
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Early host interactions that drive the dysregulated response in sepsis.

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journal contribution
posted on 2021-03-29, 13:25 authored by Steven KerriganSteven Kerrigan, Tatyana Devine, Glenn Fitzpatrick, Jecko Thachil, Dermot CoxDermot Cox
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. While many individual cells and systems in the body are involved in driving the excessive and sometimes sustained host response, pathogen engagement with endothelial cells and platelets early in sepsis progression, are believed to be key. Significant progress has been made in establishing key molecular interactions between platelets and pathogens and endothelial cells and pathogens. This review will explore the growing number of compensatory connections between bacteria and viruses with platelets and endothelial cells and how a better understanding of these interactions are informing the field of potential novel ways to treat the dysregulated host response during sepsis.


Higher Education Authority Project grant [grant number (11/BioAT/1377E)

Science Foundation Ireland (SFI) Career Development Award (grant number 13/CDA/2119)

Health Research Board (grant number 06/RP/211)



The original article is available at

Published Citation

Kerrigan SW, Devine T, Fitzpatrick G, Thachil J, Cox D. Early host interactions that drive the dysregulated response in sepsis. Frontiers in Immunology. 2019;10:1748.

Publication Date

6 August 2019

PubMed ID



  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Vascular Biology
  • Biomaterials and Regenerative Medicine
  • Immunity, Infection and Inflammation


Frontiers Media


  • Published Version (Version of Record)