EXCLI-21-840.pdf (1.11 MB)
Effects of curcumin on low-density lipoprotein oxidation: from experimental studies to clinical practice
journal contributionposted on 2022-10-24, 15:40 authored by Fatemeh Baratzadeh, Alexandra ButlerAlexandra Butler, Prashant Kesharwani, Seyed Adel Moallem, Amirhossein Sahebkar
Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.
CommentsThe original article is available at https://www.excli.de/
Published CitationBaratzadeh F, Butler AE, Kesharwani P, Moallem SA, Sahebkar A. Effects of curcumin on low-density lipoprotein oxidation: from experimental studies to clinical practice. EXCLI J. 2022;21:840-851.
Publication Date22 June 2022
- RCSI Bahrain
- Published Version (Version of Record)