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Effects of novel glucose-lowering drugs on the lipid parameters: a systematic review and meta-analysis

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posted on 2023-11-20, 16:55 authored by Sophia Dar, Ahmed Kamal Siddiqi, Tamim Omar Alabduladhem, Ahmed Mustafa Rashid, Saba Sarfraz, Talha Maniya, Ritesh G Menezes, Talal Almas

Aim: We aim to evaluate the impacts of sodium-glucose co-transporter 2 inhibitors (SGLT-2), glucagon-like peptide 1 agonist (GLP-1RAs), and dipeptidyl peptidase-four (DPP4) inhibitors on the levels of high-density lipoprotein, low-density lipoprotein, triglyceride and total cholesterol.

Methods: The MEDLINE database was searched from inception till October 2021, for randomized controlled trials assessing the effects of sodium-glucose co-transporter two inhibitors (SGLT-2), glucagon-like peptide 1 agonist (GLP-1RAs), and dipeptidyl peptidase-four (DPP4) inhibitors on lipid levels.

Results: A total of 57 trials were included in the analysis. Our pooled analysis demonstrates that SGLT-2 inhibitors significantly increase the levels of HDL (WMD = 0.07 mg/dL [0.06 to 0.08], P < 0.00001). SGLT-2 inhibitors were also found to be significantly associated with an increase in the levels of LDL (WMD = 0.11 mg/dL, [0.09-0.13 mg/dL, P < 0.00001). Pooled analysis also demonstrates that SGLT-2 inhibitors significantly reduce the levels of triglyceride (WMD = -0.10 mg/dL, [-0.13 to -0.06], P < 0.00001). Our pooled analysis demonstrates that SGLT-2 inhibitors significantly increased the levels of total cholesterol (WMD = 0.10 mg/dL, [0.06 to 0.15], P < 0.0001), whereas, GLP-1RAs significantly reduced the levels of total cholestrol (WMD = -0.18 mg/dL, [-0.34 to -0.02], P = 0.03).

Conclusion: This is the first head-to-head study comparing the effects of 3-novel glucose-lowering agents to lipid parameters. However, more trials are crucial to better understand the impact of glucose-lowering drugs on lipid parameters.

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The original article is available at https://journals.lww.com/

Published Citation

Dar S, et al. Effects of novel glucose-lowering drugs on the lipid parameters: a systematic review and meta-analysis. Ann Med Surg (Lond). 2022;77:103633.

Publication Date

16 April 2022

PubMed ID

35637990

Department/Unit

  • Undergraduate Research

Publisher

Wolters Kluwer Health, Inc

Version

  • Published Version (Version of Record)