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Elevated plasma microRNA-206 levels predict cognitive decline and progression to dementia from mild cognitive impairment

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journal contribution
posted on 2023-01-09, 12:09 authored by Aidan Kenny, Hazel McArdle, Miguel Calero, Alberto Rabano, Stephen MaddenStephen Madden, Kellie Adamson, Robert Forster, Elaine Spain, Jochen PrehnJochen Prehn, David HenshallDavid Henshall, Miguel Medina, Eva M Jimenez-Mateos, Tobias EngelTobias Engel
The need for practical biomarkers for early diagnosis of Alzheimer’s disease (AD) remains largely unmet. Here we investigated the use of blood-based microRNAs as prognostic biomarkers for AD and their application in a novel electrochemical microfluidic device for microRNA detection. MicroRNA transcriptome was profiled in plasma from patients with mild cognitive impairment (MCI) and AD. MicroRNAs Let-7b and microRNA-206 were validated at elevated levels in MCI and AD, respectively. MicroRNA-206 displayed a strong correlation with cognitive decline and memory deficits. Longitudinal follow-ups over five years identified microRNA-206 increases preceding the onset of dementia. MicroRNA-206 was increased in unprocessed plasma of AD and MCI subjects, detected by our microfluidic device. While increased Let-7b levels in plasma may be used to identify patients with MCI, changes in plasma levels of microRNA-206 may be used to predict cognitive decline and progression towards dementia at an MCI stage. MicroRNA quantification via a microfluidic device could provide a practical cost-effective tool for the stratification of patients with MCI according to risk of developing AD.

Funding

Health Research Board HRA-POR-2015-1243

Science Foundation Ireland (12/COEN/18, 17/CDA/4708, 18/FIP/3552 and 16/RC/3948 (co-funded under the European Regional Development Fund and by FutureNeuro industry partners)

CIBERNED and the Spanish Ministry of Science (SAF2016-78603-R)

Institutional grants from the Queen Sofia Foundation

CIEN Foundation and the Carlos III Institute of Health

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Kenny A. et al. Elevated plasma microRNA-206 levels predict cognitive decline and progression to dementia from mild cognitive impairment. Biomolecules. 2019;9(11):734.

Publication Date

13 November 2019

PubMed ID

31766231

Department/Unit

  • Data Science Centre
  • FutureNeuro Centre
  • Physiology and Medical Physics

Research Area

  • Cancer
  • Neurological and Psychiatric Disorders
  • Gynaecology, Obstetrics and Perinatal Health

Publisher

MDPI

Version

  • Published Version (Version of Record)