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Endothelial cells orchestrate COVID-19 coagulopathy

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journal contribution
posted on 01.07.2021, 16:15 authored by Jamie O'SullivanJamie O'Sullivan, Dennis M Gonagle, Soracha Enright Ward, Roger PrestonRoger Preston, James O'DonnellJames O'Donnell

Recent data have shown that coagulation activation is common in patients with severe COVID-19. Moreover, autopsy studies have reported widespread microthrombi disseminated throughout the pulmonary vasculature, suggesting that vasculopathy is important in COVID-19 pathogenesis. These post-mortem studies have also highlighted substantial endothelial cell damage, with evidence of apoptosis and loss of tight junctions. Collectively, these data suggest that endothelial cells play a key role in orchestrating the unusual pulmonary intravascular coagulopathy associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.



The original article is available at https://www.thelancet.com

Published Citation

O'Sullivan JM, Gonagle DM, Ward SE, Preston RJS, O'Donnell JS. Endothelial cells orchestrate COVID-19 coagulopathy. Lancet Haematol. 2020;7(8):e553-e555.

Publication Date

30 June 2020

PubMed ID



  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Health Professions Education
  • Vascular Biology
  • Cancer
  • Immunity, Infection and Inflammation




  • Accepted Version (Postprint)