Endothelial cells orchestrate COVID-19 coagulopathy
Recent data have shown that coagulation activation is common in patients with severe COVID-19. Moreover, autopsy studies have reported widespread microthrombi disseminated throughout the pulmonary vasculature, suggesting that vasculopathy is important in COVID-19 pathogenesis. These post-mortem studies have also highlighted substantial endothelial cell damage, with evidence of apoptosis and loss of tight junctions. Collectively, these data suggest that endothelial cells play a key role in orchestrating the unusual pulmonary intravascular coagulopathy associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
CommentsThe original article is available at https://www.thelancet.com
Published CitationO'Sullivan JM, Gonagle DM, Ward SE, Preston RJS, O'Donnell JS. Endothelial cells orchestrate COVID-19 coagulopathy. Lancet Haematol. 2020;7(8):e553-e555.
Publication Date30 June 2020
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences
- Health Professions Education
- Vascular Biology
- Immunity, Infection and Inflammation
- Accepted Version (Postprint)